搴峰笇璇虹敓鐗?cansinobio-电子游戏平台

缇庡浗鍦ㄧ爺鎶楃檶鏂拌嵂鍙婄柅鑻楁姤鍛?/div>
2018-06

2018-06-19 | 涓滄柟澶存潯 |

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銆€銆€5鏈?0鏃hrma鍙戝竷2018缇庡浗鍦ㄧ爺鎶楃檶鑽墿鎶ュ憡锛屾埅鑷?018骞?鏈?鏃ワ紝缇庡浗鐢熺墿鍖昏嵂鍏徃鍦ㄧ爺鎶楄嵂鏂拌嵂鍙婄柅鑻楀叡璁?120涓€傚湪鎶楃檶鑽墿鐮斿彂绠$嚎涓紝骞冲潎85%鏄鍒涜嵂鐗?first-in-class)锛屾剰鍛崇潃瀹冧滑閲囩敤浜嗘柊鍨嬩笖鐙壒鐨勪綔鐢ㄦ満鍒躲€?120涓湪鐮旀姉鑽柊鑽強鐤嫍鍖呮嫭锛?/span>


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銆€銆€132涓敤浜庤偤鐧岋紝2018骞撮浼板皢鏈?3涓囨柊澧炵梾渚嬶紱


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銆€銆€杩戝嚑骞达紝鍒涙柊鐤楁硶鍦ㄦ姉鐧岄鍩熷彇寰椾簡宸ㄥぇ杩涙鐨勫悓鏃讹紝涔熷杩涗簡浜虹被瀵逛簬鐧岀棁鐨勮璇嗐€傚湪1120涓湪鐮旀姉鐧岃嵂鐗╁強鐤嫍涓紝寰堝灞炰簬鍒涙柊鐤楁硶锛屽叾涓寘鎷細car-t:car-t鐤楁硶鏄埄鐢ㄦ偅鑰呰嚜浣揟缁嗚優鐗瑰紓鎬у湴璇嗗埆鍜屾潃姝昏偪鐦ょ粏鑳烇紝浠庢偅鑰呰嚜浣撳垎绂诲厤鐤玊缁嗚優锛屼娇鐢ㄥ熀鍥犲伐绋嬫妧鏈粰t缁嗚優鍔犲叆涓€涓兘澶熻瘑鍒偪鐦ょ粏鑳炲悓鏃舵縺娲籘缁嗚優鐨勫祵鍚堟姉浣擄紝鍗冲埗澶嘋ar-t缁嗚優锛屽埗澶囧ソ鐨凜at-t缁嗚優閫氳繃浣撳鎵╁锛屾渶缁堝啀鎶婃墿澧炲ソ鐨凜ar-t缁嗚優鍥炶緭鍏ユ偅鑰呬綋鍐咃紝鐢ㄤ簬缁撳悎鍜屾潃姝昏偪鐦ょ粏鑳炪€?017骞?鏈?0鏃ワ紝璇哄崕鐨勫熀鍥犳不鐤楁柟娉旵ar-t缁嗚優鑽墿 kymriah(tisagenlecleucel锛孋tl-019)琚編鍥紽da鎵瑰噯涓婂競锛岀敤浜庢不鐤楀効绔ュ拰骞磋交鎴愪汉(2~25宀?鐨勬€ユ€ф穻宸寸粏鑳炵櫧琛€鐥?all)銆?/span>


銆€銆€adc:鎶椾綋-鑽墿澶嶅悎浣?antibody-drug conjugates, adc)鏄皢鍗曟姉浣?mab)閫氳繃鍖栧閾炬帴(chemical linker)涓庤兘澶熸潃姝荤檶缁嗚優鐨勮嵂鐗?cytotoxic drug)缁撳悎鍦ㄤ竴璧枫€侫dc鑳藉鐗瑰紓鍦板皢鑽墿瀵煎叆闈跺悜浣嶇偣锛屽湪鏉€姝婚澏鐐圭檶缁嗚優鐨勫悓鏃讹紝涓嶅奖鍝嶅仴搴风粏鑳炵殑鍔熻兘锛屼粠鑰岃揪鍒伴珮閫夋嫨鎬с€佷綆鍓綔鐢ㄧ殑鏄捐憲娌荤枟鏁堟灉銆傛渶鏃╄幏fda瀹℃壒鐨凙dc鑽墿涓鸿緣鐟炵殑mylotarg锛屼簬2000骞翠笂甯傜敤浜庢不鐤楁€ユ€ч珦缁嗚優鏍风櫧琛€鐥?acute myeloid leukemia锛孉ml)锛?010骞?鏈堢敱浜庝复搴婅瘯楠屾樉绀鸿鑽弽鑰屽鍔犱簡姝讳骸鐜?5.7%鐩稿瀵规瘮缁勭殑1.4%)鑰屾挙甯傘€傚湪缇庡浗锛屾湁4娆続dc鑽墿琚壒鍑嗕娇鐢ㄣ€傚厤鐤鏌ョ偣璋冭妭鍓?immune checkpointmodulators)锛氬厤鐤鏌ョ偣璋冭妭鍓傞€氳繃鎶戝埗鍏嶇柅妫€鏌ョ偣(鍏嶇柅缁嗚優浜х敓鐨勬姂鍒惰嚜韬厤鐤椿鎬х殑铔嬬櫧灏忓垎瀛?锛屼互瑙i櫎鑲跨槫缁嗚優鐨勯€冮€告満鍒讹紝璁╁厤鐤粏鑳為噸鏂版縺娲诲伐浣滐紝浠庤€屾秷鐏檶缁嗚優銆傜幇浠婄殑鍏嶇柅妫€鏌ョ偣璋冭妭鍓備富瑕佷綔鐢ㄤ簬ctla-4, ox40鍜孭d-1/pd-l1銆?011骞?鏈?5鏃ワ紝fda鎵瑰噯浼婂尮鍗曟姉(鐧炬椂缇庢柦璐靛疂ipilimumab锛孻ervoy)鐢ㄤ簬娌荤枟涓嶈兘鍒囬櫎鎴栬浆绉荤殑榛戣壊绱犵槫銆傞櫎姝や互澶栵紝fda杩樻壒鍑嗕簡甯曞鍗曟姉(pembrolizumab)銆佺撼姝﹀崟鎶?nivolumab)銆侀樋鐗圭彔鍗曟姉(atezolizumab)銆侀樋缁村崟鎶?avelumab)鍜孌urvalumab銆?/span>


銆€銆€浠h阿鍏嶇柅鐤楁硶(metabolic immunotherapy)锛氫唬璋㈠厤鐤枟娉曢€氳繃浣跨敤浠h阿閫斿緞鎻愰珮鍏嶇柅绯荤粺瀵圭檶缁嗚優鐨勬敾鍑昏兘鍔涳紝甯屾湜璋冭妭鍏嶇柅绯荤粺娲诲姩锛岄€氳繃浣滅敤浜庡叧閿唬璋㈤叾鎻愰珮鍏嶇柅绯荤粺锛屾縺娲绘姉鑲跨槫鍙嶅簲銆?017骞?鏈?鏃da鎵瑰噯鏂板熀鍏徃idhifa (enasidenib)涓婂競锛岀敤浜庢不鐤楁惡甯﹀紓鏌犳閰歌劚姘㈤叾2(idh2)鍩哄洜绐佸彉鐨勬垚浜哄鍙戞垨闅炬不鎬ф€ユ€ч珦绯荤櫧琛€鐥呫€?/span>


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